ABSTRACT
To determine the risk factors and complications of hepatitis C in a tertiary care hospital in Peshawar. Prospective observational study. Medicine department, Khyber Teaching Hospital Peshawar. From April 2004 to June 2005. A total of 252 HCV positive patients were selected, 165 were males and 87 were females. Relevant information was obtained from the patients with the help of a predesignd questionnaire prepared in accordance with the objectives of the study. The age range of patients was from 11 years to 84 years with mean age of47.5 years. Out of total sampling 137[54.36%] patients had positive family history of hepatitis C virus [HCV]. Risk factors distribution was: intravenous drug users 73, HCV positive sexual partners 58 [23.01%], blood or blood product transfusion 34[13.49%] and occupational acquired HCV 18[7.14%]. Unknown source of HCV transmission was recorded in 69[27.38%]. Clinical presentation of HCV positive patient was: Chronic persistent hepatitis 87[34.52%], liver cirrhosis 41[16.26%], hepatocellular carcinoma 2[0.79%] and fulminant hepatitis 2[0.79%]. One hundred and twenty patients [47.61%] were asymptomatic or subclinical symptomatic. Intravenous drug abuse and HCV positive sexual partners [wife or husband] were found as major risk factors of HCV transmission and chronic persistent hepatitis and liver cirrhosis were recorded as major clinical presentations of HCV in our patients
ABSTRACT
To determine the frequency of G6PD deficiency in the etiology of anaemia and jaundice and to determine the most common age of presentation with anaemia and jaundice due to G6PD deficiency in adults. We did a hospital based study in the department of Medicine Khyber Teaching Hospital Peshawar from June 2003 to December 2003. The data of adult patients with signs and symptoms of anaemia and jaundice was collected on structured proforma. The clinical presentation and laboratory investigation results were documented. Out of 200 patients studied, 24 [12%] patients were found to be deficient in G6PD enzyme. The male to female ratio was 21:3 [87.5% and 12.5%] respectively. The age of appearance of jaundice in adults varied [most common age from 13 to 17 years]. The most common signs and symptoms were jaundice, anaemia and haemoglobinuria. All G6PD deficient patients except one recovered spontaneously when the offending precipltating factor were stopped or treated. One [0.5%] died because of rapid fall of haemoglobin and delayed recognition of the condition and subsequent blood transfusion. G6PD deficiency is not an uncommon cause of jaundice and anaemia in our patients. The jaundice due to G6PD mainly affects the adults in 2nd or 3rd decade. Therefore all the children and adults with jaundice and anaemia should be screened for G6PD status